No, current research does not show that Testosterone Replacement Therapy (TRT) causes cancer. In particular, there is no strong evidence linking TRT to an increased risk of prostate cancer. While older studies raised concerns, modern research shows TRT is generally safe for most men when monitored properly.
Testosteron can cause Prostate Cancer?
For decades, doctors believed testosterone might fuel prostate cancer growth. This belief came from 1940s research that showed lowering testosterone slowed the progression of advanced prostate cancer. Naturally, this led to the fear that raising testosterone through TRT could trigger or speed up cancer.
But modern studies paint a different picture.
One large study by Dr. Abraham Morgentaler, a leading researcher in men’s health, found no clear link between TRT and prostate cancer. In fact, prostate cancer often develops in older men due to age—not testosterone.
Another key idea, the saturation model, explains this better: prostate cells only need a small amount of testosterone to grow. Once this level is reached, more testosterone doesn’t increase growth, meaning TRT is unlikely to cause or worsen prostate cancer in healthy men.
TRT and Other Types of Cancer
Aside from prostate cancer, some people ask if TRT increases the risk of testicular cancer or breast cancer in men. As of now, there’s no strong evidence connecting TRT to these cancers.
However, TRT can increase red blood cell production, leading to a condition called polycythemia—which thickens the blood and may raise the risk of blood clots or cardiovascular issues if not monitored.
Who Should Be Cautious for Hormone Therapy?
While TRT is safe for most men, it’s important to be cautious if you:
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Have a family history of prostate cancer
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Have previously been diagnosed with prostate cancer
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Are over 50 and haven’t had regular PSA testing or prostate screening
At Nova Men’s Health, we always recommend PSA blood tests and digital rectal exams (DRE) before and during TRT to ensure prostate health is regularly checked.
Does TRT Cause Cancer?
No, TRT does not cause cancer, according to the latest research. Still, if you’re at higher risk—due to age, family history, or past prostate issues—working closely with a medical expert is essential. At Nova Men’s Health, we tailor every TRT plan with safety, regular testing, and long-term health in mind.